A Better Way to Prep

ZeraFlow aims to improve on traditional bowel preparation with about a 30-minute, clinically supervised warm-water cleanse performed immediately before colonoscopy.

I'm a patient

I'm a clinician or ASC

71% of colonoscopy patients say the prep is the worst part.¹ For millions, it’s why they delay or avoid screening altogether. ZeraFlow was built to change that.

THE COMPARISON

Traditional Prep vs. ZeraFlow

    
    Traditional Oral Prep
    ZeraFlow
  
    The day before
    Liquid or Oral laxatives limiting mobility away from home
    OTC laxative with no impact to daily routine²
  
    Where prep happens
    At home, alone, uncontrolled
    At the clinic, staff-supervised
  
    Time commitment
    24-48 hour home prep
    Arrive 60 minutes prior to colonoscopy
  
    Side effects
    Nausea, bloating, sleep disruption
    Warm water, minimal discomfort³
  
    Dignity
    Hours spent near a bathroom
    Private, supervised clinical setting
  
    Prep adequacy
    30% inadequate prep⁵
    89.4% adequate prep⁴

	Traditional Oral Prep	ZeraFlow
The day before	Liquid or Oral laxatives limiting mobility away from home	OTC laxative with no impact to daily routine²
Where prep happens	At home, alone, uncontrolled	At the clinic, staff-supervised
Time commitment	24-48 hour home prep	Arrive 60 minutes prior to colonoscopy
Side effects	Nausea, bloating, sleep disruption	Warm water, minimal discomfort³
Dignity	Hours spent near a bathroom	Private, supervised clinical setting
Prep adequacy	30% inadequate prep⁵	89.4% adequate prep⁴

Three steps. That is all.

Take your tablets (the night before)

Three mild laxative tablets the night before. No liquid prep. Follow your clinic's dietary instructions. Just a light dinner.
Arrive at your clinic

Come in the morning of your colonoscopy as you normally would. Your care team takes it from here.
Complete your ZeraFlow prep

Designed to complete prep in about 30 minutes before your procedure begins.

The numbers behind ZeraFlow

33 min

Zero

Median prep time, published clinical study⁸

Device-related serious adverse events⁹

98.4%

89.4%

enrolled patients completed the prep as defined by the protocol⁷

Prep adequacy rate⁶

WHO BENEFITS

Better prep. Better procedures.

For Patients

No large-volume liquid prep at home. No gallons. No disruption. In and out in about 30 minutes, fully supervised. Same-day return to normal activity (published clinical study).¹⁰

For Clinicians

Consistently reliable prep quality. Designed to reduce day-of cancellations. Cleaner procedures. Turn the prep step into a revenue step.

For Healthcare Systems

Designed to support higher screening completion rates by reducing prep-related avoidance, the most commonly cited barrier to colonoscopy. Fewer repeat procedures from inadequate preparation.¹¹

ZeraFlow is coming to clinics near you.

Be the first to know when ZeraFlow is available at a clinic in your area.

The ZeraFlow Colon Irrigation Kit is intended for mechanical cleansing of the colon when medically indicated, such as before radiological or endoscopic examination. The device is intended for prescription use only.

1 Vemulapalli KC, Lahr RE, Rex DK. 2021 Patient Perceptions Regarding Colonoscopy Experience. Journal of Clinical Gastroenterology. 2023;57(4):400-403. https://pubmed.ncbi.nlm.nih.gov/35324481/
2 Ziv Y, Scapa E. Techniques in Coloproctology. 2013;17:39-44. https://link.springer.com/article/10.1007/s10151-012-0876-8
3 In clinical evaluation, 1.6% of patients reported mild transient nausea. No severe pain or cramping was reported. Source: Ziv Y, Scapa E. Techniques in Coloproctology. 2013;17:39-44. https://link.springer.com/article/10.1007/s10151-012-0876-8
4 Source: Zera Medical Clinical Outcomes Registry / 510(k) submission. Data on file.
5 Strategies to Improve Inadequate Bowel Preparation for Colonoscopy https://pmc.ncbi.nlm.nih.gov/articles/PMC6857107/
6 Source: Zera Medical Clinical Outcomes Registry / 510(k) submission. Data on file.
7 Ziv Y, Scapa E. Techniques in Coloproctology. 2013;17:39-44. (123 of 125 patients completed the preparation process.) https://link.springer.com/article/10.1007/s10151-012-0876-8
8 Ziv Y, Scapa E. Techniques in Coloproctology. 2013;17:39-44. Median preparation time 33 minutes, range 20-60 min, n=125. https://link.springer.com/article/10.1007/s10151-012-0876-8
9 Ziv Y, Scapa E. Techniques in Coloproctology. 2013;17:39-44. https://link.springer.com/article/10.1007/s10151-012-0876-8
10 Ziv Y, Scapa E. Techniques in Coloproctology. 2013;17:39-44. All patients in the study returned to normal activities the same day. https://link.springer.com/article/10.1007/s10151-012-0876-8
11 Screening avoidance: McLachlan SA, Clements A, Austoker J. J Clin Oncol. 2009;27(Suppl):S15. https://ascopubs.org/doi/10.1200/jco.2009.27.15_suppl.s15 | Repeat procedures: Hassan C et al. PLOS ONE. 2016;11(1):e0147981. https://pmc.ncbi.nlm.nih.gov/articles/PMC8082895/